Is In Simple

import numpy as np
a = np.array([
    [1, 2],
    [3, 4]
])
a
array([[1, 2],
       [3, 4]])

b = [1, 1, 5, 3]
c = np.isin(a, b)
c
array([[ True, False],
       [ True, False]])

# Invert can be done as well
d = np.isin(a, b, invert=True)
d
array([[False,  True],
       [False,  True]])